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  1. Home
  3. Characteristics Associated With Poor Long-term Outcomes In Patients With Fontan Palliation: A Case-control Study.
  1. Home
  3. Characteristics Associated With Poor Long-term Outcomes In Patients With Fontan Palliation: A Case-control Study.

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Related Experiment Video

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring
06:29

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring

Published on: May 2, 2025

Characteristics Associated with Poor Long-Term Outcomes in Patients with Fontan Palliation: A Case-Control Study.

Anusha Konduri1, Sunkyung Yu2, Scott Breshears2

  • 1Children's Health, University of Texas Southwestern Medical Center, Dallas, TX, USA. Anusha.Konduri@UTSouthwestern.edu.

Pediatric Cardiology
|June 26, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Identifying patients at risk after Fontan procedure is crucial. Systemic right ventricular morphology, high pre-Fontan pressures, and long hospital stays predict Fontan circulatory failure, guiding better patient management.

Keywords:
Congenital heart diseaseFontan circulationFontan failureFontan outcomesGlenn pressureHeart transplantationSingle ventricleVentricular morphology

Related Experiment Videos

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring
06:29

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring

Published on: May 2, 2025

Area of Science:

  • Congenital Heart Disease
  • Pediatric Cardiology
  • Cardiovascular Surgery

Background:

  • The Fontan procedure offers palliation for single-ventricle physiology but is limited by progressive Fontan circulatory failure.
  • Early identification of high-risk patients is essential for effective surveillance and management strategies.

Purpose of the Study:

  • To identify peri-Fontan factors associated with mortality or the need for advanced cardiac therapies in patients who have undergone the Fontan procedure.

Main Methods:

  • A retrospective matched case-control study was conducted involving patients who completed the Fontan procedure between 2000 and 2023.
  • Cases were defined as patients experiencing death, ventricular assist device (VAD) implantation, or heart transplantation post-Fontan.
  • Conditional logistic regression analyzed pre-Fontan hemodynamics, cardiac anatomy, and perioperative variables.

Main Results:

  • Systemic right ventricular morphology (aOR 6.87), pre-Fontan Glenn/hemi-Fontan pressure > 12 mmHg (aOR 4.72), and postoperative hospital length of stay > 12 days (aOR 8.57) were independently associated with adverse outcomes.
  • The median age at Fontan failure was 11.5 years, occurring 8.6 years post-procedure.

Conclusions:

  • Systemic right ventricular morphology, elevated pre-Fontan pressures, and prolonged postoperative hospitalization are key predictors of long-term adverse outcomes after Fontan completion.
  • These findings highlight the importance of perioperative hemodynamics and postoperative recovery in assessing long-term Fontan risk.