Related Experiment Video

Updated: Jun 4, 2026

Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure
05:18

Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure

Published on: January 16, 2026

The Ninth Annual STS-Pedimacs Report: Pediatric Ventricular Assist Device Outcomes and the Expanding Role of

Shahnawaz Amdani1, David M Peng2, Jonathan B Edelson3

  • 1Division of Cardiology & Cardiovascular Medicine, Cleveland Clinic Children's, Cleveland, Ohio.

The Annals of Thoracic Surgery
|June 2, 2026
PubMed

Insights

Outcomes for pediatric ventricular assist device (VAD) support are improving. The Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) report shows better survival rates for children with heart failure, especially those with cardiomyopathy.

Area of Science:

  • Pediatric cardiology
  • Mechanical circulatory support
  • Congenital heart disease

Background:

  • The Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) provides critical data on pediatric ventricular assist device (VAD) use.
  • This report focuses on VAD outcomes, including biventricular support, in children.

Purpose of the Study:

  • To present the most comprehensive update on pediatric VAD outcomes.
  • To analyze trends and differences in VAD support for children with end-stage heart failure.

Main Methods:

  • Analysis of data from the Pedimacs registry.
  • Inclusion of 1465 patients who underwent VAD implantation between September 19, 2012, and December 31, 2024.

Main Results:

  • Congenital heart disease (CHD) is an increasing reason for VAD implantation (28%).
  • Survival at 6 months and 1 year on VAD support was 77% and 73%, respectively.
  • Survival rates have shown successive improvement over time (2012-2024), with better outcomes for ages 11-19, cardiomyopathy patients, and those receiving implantable continuous (IC) VADs.
  • Biventricular assist device (BiVAD) patients had higher pre-implant acuity and lower survival compared to left ventricular assist device (LVAD) recipients.

Conclusions:

  • Pediatric VAD support is increasing for children with end-stage heart failure, with progressively improving outcomes.
  • Significant variations in clinical characteristics and outcomes exist based on VAD type and underlying condition (e.g., single ventricle CHD vs. cardiomyopathy).
  • This report offers a detailed analysis of pediatric patients receiving biventricular support.
Abstract

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