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Bisphosphonate-related osteonecrosis of the jaw
Mariana Aparecida Brozoski1, Andreia Aparecida Traina, Maria Cristina Zindel Deboni
1Faculdade de Odontologia, Universidade de São Paulo – USP.
Abstract:
Bisphosphonates (BPs) have been used for the management of bone metabolic diseases. Currently their therapeutic use has increased, as also have their adverse effects, one of the most important being the bisphosphonate-related osteonecrosis of the jaw (BRONJ), a complication of difficult treatment and solution. Until now, the physiopathology of BRONJ remains unclear, and its treatment is uncertain. Although the literature provides several treatment options, there is no defined protocol. We present a review about BRONJ, focusing on its pathogenesis and its reported forms of treatment.
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