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DIC Score: Statistical Relationship with PT, APTT, and Simplified Scoring Systems with Combinations of PT and APTT

Vani Chandrashekar1

  • 1Department of Hematology, Apollo Hospitals, 21, Greams Lane, Off Greams Road, Chennai, Tamil Nadu 600006, India.

ISRN Hematology
|March 31, 2012
PubMed

Insights

Prothrombin time (PT) and activated partial thromboplastin time (APTT) can help predict disseminated intravascular coagulation (DIC) scores. PT, PT + APTT, and PT/APTT ratios showed statistical significance in predicting DIC, unlike APTT alone.

Area of Science:

  • Hematology
  • Clinical Pathology

Background:

  • Disseminated intravascular coagulation (DIC) is a life-threatening condition.
  • Accurate and timely diagnosis of DIC is crucial for effective management.
  • The International Society on Thrombosis and Haemostasis (ISTH) developed a scoring system for DIC diagnosis.

Purpose of the Study:

  • To evaluate the statistical association between prothrombin time (PT) and activated partial thromboplastin time (APTT) and the ISTH DIC score.
  • To determine the predictive value of PT and APTT, individually and in combination, for DIC.
  • To assess if the ISTH DIC scoring system can be utilized without d-dimer and platelet count.

Main Methods:

  • Linear regression analysis was employed to assess the association between coagulation parameters and the DIC score.
  • Fifty inpatients with suspected DIC were included in the study.
  • Prothrombin time (PT), activated partial thromboplastin time (APTT), PT + APTT, and PT/APTT ratios were analyzed.

Main Results:

  • PT, PT + APTT, and PT/APTT ratios were statistically significant predictors of the DIC score (P=0.02, P=0.03, P=0.02, respectively).
  • APTT alone was not a statistically significant predictor of the DIC score (P=0.09).
  • The study suggests that the ISTH DIC scoring system is effective without requiring d-dimer levels or platelet counts.

Conclusions:

  • PT and its ratios with APTT are valuable in predicting DIC scores.
  • APTT alone has limited predictive value for DIC in this cohort.
  • The ISTH DIC scoring system offers a viable diagnostic approach without necessitating d-dimer or platelet count measurements.

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