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Angiotensin peptides and nitric oxide in cardiovascular disease

Kaushik P Patel1, Harold D Schultz

  • 11 Department of Cellular and Integrative Physiology, University of Nebraska Medical Center , Omaha, Nebraska.

Antioxidants & Redox Signaling
|April 3, 2012
PubMed
Abstract

Insights

The renin-angiotensin system (RAS) is crucial for cardiovascular health. Imbalances in RAS pathways, particularly involving oxidative stress, contribute to cardiovascular diseases like hypertension and heart failure.

Area of Science:

  • Cardiovascular Physiology
  • Renal Function
  • Neuroendocrinology

Background:

  • The renin-angiotensin system (RAS) is vital for cardiovascular and renal homeostasis.
  • A balance between the ACE/Ang II/AT1 receptor and ACE2/Ang-(1-7)/Mas receptor axes is critical for normal function.
  • Imbalances favoring the ACE/Ang II/AT1 axis are linked to cardiovascular diseases (CVD).

Purpose of the Study:

  • To elucidate the mechanisms disrupting RAS regulation in CVD.
  • To understand the role of oxidative and nitrosative pathways in neural control of circulation.
  • To investigate the interplay between redox mechanisms and RAS enzyme/receptor activity.

Main Methods:

  • Analysis of renin-angiotensin system (RAS) pathways.
  • Investigation of ACE and ACE2 expression and function.
  • Exploration of neural control mechanisms involving oxidative and NO• pathways.

Main Results:

  • Key mechanisms disrupting Ang II and Ang-(1-7) signaling in CVD remain unclear.
  • ACE and ACE2 expression and function appear interdependent.
  • Oxidative and nitrosative pathway interactions may be central to disease pathogenesis.

Conclusions:

  • Understanding redox mechanisms controlling RAS components is key to understanding local tissue RAS in health and disease.
  • Imbalances in RAS signaling contribute significantly to cardiovascular disease progression.
  • Further research into the interplay of redox and RAS is warranted.

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