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GLP-1 Receptor Agonists: From Clinical Success to Mechanistic Insight

Tapan A Patel1, Jill Rose1, Kenichi Katsurada2,3

  • 1Department of Cellular and Integrative Physiology (T.A.P., J.R., P.K., J.S., K.P.P., M.A.), University of Nebraska Medical Center, Omaha.

Circulation Research
|July 16, 2026
PubMed
Summary

Glucagon-like peptide-1 receptor (GLP-1R) agonists offer new hypertension and cardiometabolic syndrome treatments by targeting vascular-metabolic biology. They show promise for cardiovascular and heart failure outcomes, with research focusing on direct signaling and personalized therapies.

Keywords:
blood pressurecardiovascular diseasesglucagon-like peptide-1 receptor agonistsheart failurerisk factors

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