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Related Concept Videos

Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

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Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining. Bicarbonate,...
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Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
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Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
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A Novel Method for the Culture and Polarized Stimulation of Human Intestinal Mucosa Explants
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Published on: May 1, 2013

Helminthic therapy: improving mucosal barrier function.

Martin J Wolff1, Mara J Broadhurst, P'ng Loke

  • 1Division of Gastroenterology, Department of Medicine, New York University School of Medicine, New York, NY 10010, USA.

Trends in Parasitology
|April 3, 2012
PubMed
Summary
This summary is machine-generated.

Helminthic therapy, using controlled exposure to worms, shows promise for autoimmune diseases. Beyond immune regulation, enhanced mucosal barrier function may be key to treating inflammatory bowel diseases.

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Area of Science:

  • Immunology
  • Gastroenterology
  • Parasitology

Background:

  • Epidemiological links between autoimmune diseases and helminth infections suggest therapeutic potential.
  • Animal models and clinical studies explore helminthic therapy for inflammatory conditions.

Purpose of the Study:

  • To review recent clinical trials of helminthic therapy for autoimmune diseases.
  • To examine the mechanisms of action, focusing on immune regulation and mucosal barrier function.

Main Methods:

  • Review of recent clinical trials on helminthic therapy.
  • Analysis of proposed mechanisms, including immune modulation and barrier enhancement.

Main Results:

  • Helminthic therapy is being investigated for safe and controlled reintroduction in patients with autoimmune diseases.
  • Proposed mechanisms include immune regulatory pathways and enhancement of mucosal barrier integrity.

Conclusions:

  • Helminthic therapy offers a novel approach to managing autoimmune and inflammatory conditions.
  • Enhancement of mucosal barrier function may play a significant role, particularly in inflammatory bowel diseases.