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Comparison between two absolute methods used for 177Lu activity measurements and its standardization.

M Capogni¹, M L Cozzella, P De Felice

¹ENEA Istituto Nazionale di Metrologia delle Radiazioni Ionizzanti (INMRI), Centro Ricerche Casaccia, I-00123 Rome, Italy. marco.capogni@casaccia.enea.it

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|April 3, 2012

Summary

A new primary standard for Lutetium-177 ((177)Lu) activity measurement was developed, ensuring accurate calibration of ionization chambers for medical applications. This advancement supports precise activity determination of short-lived radionuclides crucial for nuclear medicine.

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Area of Science:

Nuclear Physics
Metrology
Radiochemistry

Background:

Accurate activity standardization of radionuclides is essential for their safe and effective use in medicine.
Lutetium-177 ((177)Lu) is a key therapeutic radionuclide with increasing medical applications.
International comparisons are vital for ensuring the consistency and reliability of radioactivity measurements worldwide.

Purpose of the Study:

To develop a primary standard for (177)Lu activity at ENEA-INMRI.
To validate the developed standard through international comparison and inter-method comparison.
To calibrate ionization chambers for routine measurements of short-lived radionuclides.

Main Methods:

Standardization of (177)Lu solution using the CIEMAT/NIST method with a tritium ((3)H) tracer.
Comparison of activity measurements with the 4πγ integral counting method.
Identification and quantification of the (177m)Lu impurity in the (177)Lu solution.
Calibration of well-type ionization chambers using the primary standard.

Main Results:

The (177)Lu primary standard was successfully developed and validated.
Results from the CIEMAT/NIST method and 4πγ integral counting showed good agreement.
The arithmetic mean of the measured values aligned well with the Comparison Reference Value (CRV).
Ionization chambers were calibrated with an uncertainty below 2%.

Conclusions:

The developed (177)Lu primary standard is reliable and accurate.
The new standard enables precise calibration of instruments for medical radionuclide applications.
This work contributes to the metrology of medically relevant radionuclides.