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Related Experiment Video

Updated: May 23, 2026

Visualizing the Developing Brain in Living Zebrafish using Brainbow and Time-lapse Confocal Imaging
07:28

Visualizing the Developing Brain in Living Zebrafish using Brainbow and Time-lapse Confocal Imaging

Published on: March 23, 2020

Studying cellular and subcellular dynamics in the developing zebrafish nervous system.

Jennifer C Hocking1, Martin Distel, Reinhard W Köster

  • 1Zoological Institute, Division of Cell Biology and Cell Physiology, Technische Universität Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany. jhocking@ualberta.ca

Experimental Neurology
|April 3, 2012
PubMed
Summary

Live imaging of embryonic zebrafish reveals dynamic cell division, neuronal migration, and axon/dendrite formation. This approach offers unprecedented insights into nervous system development.

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Area of Science:

  • Developmental Neuroscience
  • Cell Biology
  • Genetics

Background:

  • Developing nervous systems exhibit complex cellular processes including proliferation, migration, and differentiation.
  • Understanding these dynamic changes requires advanced imaging techniques capable of observing cellular and subcellular events in real-time.
  • The transparent embryonic zebrafish is a powerful model organism for in vivo studies due to its optical clarity.

Purpose of the Study:

  • To highlight the utility of time-lapse in vivo imaging in studying nervous system development.
  • To showcase the application of genetic tools in zebrafish for precise control of fluorescent protein expression.
  • To provide insights into dynamic cellular processes during neural development.

Main Methods:

  • Utilized time-lapse in vivo imaging techniques.

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Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development
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Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development

Published on: February 28, 2014

Live Imaging of Cell Motility and Actin Cytoskeleton of Individual Neurons and Neural Crest Cells in Zebrafish Embryos
10:52

Live Imaging of Cell Motility and Actin Cytoskeleton of Individual Neurons and Neural Crest Cells in Zebrafish Embryos

Published on: February 3, 2010

Related Experiment Videos

Last Updated: May 23, 2026

Visualizing the Developing Brain in Living Zebrafish using Brainbow and Time-lapse Confocal Imaging
07:28

Visualizing the Developing Brain in Living Zebrafish using Brainbow and Time-lapse Confocal Imaging

Published on: March 23, 2020

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development
05:36

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development

Published on: February 28, 2014

Live Imaging of Cell Motility and Actin Cytoskeleton of Individual Neurons and Neural Crest Cells in Zebrafish Embryos
10:52

Live Imaging of Cell Motility and Actin Cytoskeleton of Individual Neurons and Neural Crest Cells in Zebrafish Embryos

Published on: February 3, 2010

  • Employed zebrafish as a transparent model organism.
  • Leveraged genetic techniques for spatial, temporal, and quantitative control of fluorescent protein expression.

    • Main Results:

    • Observed dynamic cell division during nervous system development.
    • Documented long-range neuronal migration.
    • Visualized the formation of axons and dendrites in real-time.

    Conclusions:

    • Time-lapse in vivo imaging in zebrafish provides crucial insights into dynamic cellular processes.
    • Genetic manipulation in zebrafish allows for detailed visualization of specific neural structures.
    • This approach heralds a new era for understanding nervous system development through live imaging.