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Four new sesquiterpenes from Commiphora myrrha and their neuroprotective effects
Jing Xu1, Yuanqiang Guo, Peng Zhao
1College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
Fitoterapia
|April 3, 2012
Abstract:
Four new sesquiterpenes, myrrhterpenoids K-N (1-4) have been isolated from the resin of Commiphora myrrha. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HR-ESIMS, 1D and 2D NMR). Compounds 1 and 4 showed neuroprotective effects against MPP(+)-induced neuronal cell death in SH-SY5Y cells.