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Effect of motion on the ADC quantification accuracy of whole-body DWIBS
Alan J Stone1, Jacinta E Browne, Brian Lennon
1Centre for Advanced Medical Imaging, St. James's Hospital/Trinity College, University of Dublin, Dublin, Ireland. stonea9@cf.ac.uk
Background And Methods:
Diffusion-weighted whole-body imaging with background body signal subtraction was introduced as a qualitative approach to detecting metastases in the body. A liver-mimicking phantom with embedded tumours that could be moved to replicate respiratory motion was developed to assess its ability to accurately quantify ADC values.
Results:
Mean tumour ADC values were unaltered by the motion; however, a significant (p < 0.05) increase in the spread of ADC values was measured, even for relatively large tumours.
Conclusions:
These findings may be of significance in cancer therapy monitoring where subtle changes in ADC histograms may reveal changes in tumour heterogeneity.
