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Updated: May 23, 2026

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
Published on: September 26, 2016
Disentangling diffusion information of individual components in a mixture with a 3D COMPACT-IDOSY NMR experiment
Matsyendranath Shukla1, Kavita Dorai
1Department of Physics, Indian Institute of Science Education & Research (IISER) Mohali, Sector 81 Manauli PO, SAS Nagar, 140306, Punjab, India.
Abstract:
A new 3D diffusion-ordered heteronuclear NMR experiment COMPACT-IDOSY (cross-polarization optimized multisite polarized accelerated time internally encoded diffusion ordered spectroscopy) has been designed and experimentally implemented on a mixture of flavonoids rutin and quercetin. The pulse sequence uses a cross-polarization mixing period and diffusion encoding gradients internally incorporated into the coherence transfer interval of a long-range heteronuclear correlation experiment. Substantial reduction in experimental time, good sensitivity and excellent resolution of signal overlap lead to the accurate determination of translational diffusion coefficients of individual components in the mixture.
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