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PER3 polymorphism and insomnia severity in alcohol dependence.
Kirk J Brower1, Marcin Wojnar, Elzbieta Sliwerska
1Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. kbrower@umich.edu
Sleep
|April 3, 2012
Summary
The PER3 gene variant influences insomnia severity in alcohol-dependent patients. Specifically, the PER3(4/4) genotype is linked to more severe insomnia symptoms in this population.
Area of Science:
- Sleep Medicine
- Genetics
- Addiction Psychiatry
Background:
- Insomnia is a prevalent and persistent issue in alcohol-dependent (AD) patients, often linked to relapse.
- AD patients frequently exhibit disrupted circadian rhythms and sleep drive, potentially influenced by genetic factors.
Purpose of the Study:
- To investigate the impact of a specific PER3 gene polymorphism on insomnia severity among individuals with alcohol dependence.
- To determine if the PER3 genotype independently predicts insomnia severity in AD patients.
Main Methods:
- A cross-sectional study analyzed patient characteristics, PER3 genotype, and insomnia severity in 285 alcohol-dependent patients.
- Hierarchical multiple linear regression was employed to identify independent predictors of insomnia severity.
Main Results:
- PER3 genotype, drinking frequency, health status, and childhood abuse independently predicted insomnia severity, explaining 28.9% of the variance.
- The PER3(4/4) genotype was associated with the highest insomnia symptom severity.
- Including PER3 genotype significantly increased the explained variance by 1.1% (P = 0.027).
Conclusions:
- The PER3 genotype is a significant, independent predictor of insomnia severity in alcohol-dependent individuals.
- These findings suggest a genetic component influencing sleep regulation in AD patients experiencing insomnia.
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