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Formulation and characterization of modified release tablets containing isoniazid using swellable polymers
M F Akhtar1, M Rabbani, A Sharif
1Bahauddin Zakariya University, Multan, Pakistan.
Summary
Modified release isoniazid tablets were developed using polyvinyl acetate (PVAc) and sodium-carboxymethylcellulose (Na-CMC). Specific polymer ratios achieved zero-order drug release, indicating potential for controlled delivery of water-soluble drugs.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Materials Science
Background:
- Isoniazid is a crucial first-line anti-tuberculosis drug.
- Achieving optimal drug release profiles is essential for effective tuberculosis treatment.
- Modified-release formulations can improve patient compliance and therapeutic outcomes.
Purpose of the Study:
- To develop swellable modified-release (MR) isoniazid tablets.
- To investigate the influence of polyvinyl acetate (PVAc) and sodium-carboxymethylcellulose (Na-CMC) combinations on drug release.
- To achieve a zero-order release profile for isoniazid.
Main Methods:
- Granules prepared via moist granulation, then compressed into tablets.
- In vitro release studies conducted over 12 hours in various pH dissolution media (1.2, 4.5, 7.0, 7.5).
- Drug release kinetics analyzed using Korsmeyer-Peppas modeling.
Main Results:
- All formulations exhibited good physical tablet quality.
- Increased polymer content enhanced drug release retardation.
- A formulation with 35% polymer content and a PVAc to Na-CMC ratio of 20:80 demonstrated zero-order release kinetics.
- Non-Fickian transport was identified as the primary release mechanism.
Conclusions:
- PVAc and Na-CMC combinations are effective in developing swellable MR isoniazid tablets.
- A specific ratio of PVAc to Na-CMC can achieve zero-order drug release.
- This approach shows feasibility for formulating zero-order release tablets of water-soluble drugs like isoniazid.
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