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Updated: May 23, 2026

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography
Published on: January 17, 2020
[Direct determination of 21 elements in serum by dynamic reaction cell inductively coupled plasma mass spectrometry]
Hui-ling Li1, Jing Ma, Yang Zhang
1Department of Occupationgl Disease and Toxication, Chaoyang Hospital Affiliated to the Capital University of Medical Science, Beijing 100020, China.
Objective:
To establish a method to directly determine 21 elements in serum by dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS).
Methods:
The serum samples were diluted with 1% nitric acid by 3 times. The inductively coupled plasma mass spectrometry (ICP-MS) was used simultaneously to detect the serum concentrations of 21 elements (Be, Al, Mn, V, Cr, Fe, Co, Ni, Cu, Zn, As, Se, Mo, Ag, Cd, Sb, Ba, T1, Ph, Th, U).
Results:
The detection limits of all elements were between 0.001-0.0711 g/1. Standard linear correlation coefficients (r) were 50.999. Standard deviations were less than 5%,the recovery rates were 90%-114%. Standard reference materials were used for quality control standards and the analysis results conformed with the certified values.
Conclusion:
The present method is a simple, rapid,sensitive and accurate method for detecting the serum samples.
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