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Updated: May 23, 2026
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Measurement of Extracellular Ion Fluxes Using the Ion-selective Self-referencing Microelectrode Technique
Published on: May 3, 2015
[Evaluating the uncertainty in urinary fluoride measurement by ion selective electrode method]
Jian Zhang1, Shu-lan Zhao, Wan-chao Zhang
1Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
Summary
This study quantifies measurement uncertainty for urinary fluoride, crucial for accurate health assessments. The method
Area of Science:
- Analytical Chemistry
- Environmental Health Science
- Clinical Chemistry
Background:
- Accurate measurement of urinary fluoride is essential for monitoring fluoride exposure and assessing health risks.
- Understanding measurement uncertainty is critical for reliable diagnostic and epidemiological studies.
Purpose of the Study:
- To evaluate the measurement uncertainty of urinary fluoride determinations.
- To establish quality assurance protocols for urinary fluoride analysis.
Main Methods:
- The study followed established principles and methods for evaluating measurement uncertainty.
- Standard statistical and analytical chemistry techniques were employed.
Main Results:
- The combined standard uncertainty for the present method was determined to be 2.86%.
- For a sample containing 4.47 mg/L of urinary fluoride, the expanded uncertainty was calculated as 0.26 mg/L.
Conclusions:
- The primary sources of uncertainty in the current method include sample repeatability, standard solution preparation, calibration curve linearity, and instrument variability.
- These findings provide a basis for improving the accuracy and reliability of urinary fluoride measurements.
