Design of a high-throughput flow perfusion bioreactor system for tissue engineering

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Rebecca L Dahlin1, Ville V Meretoja, Mengwei Ni

  • 1Department of Bioengineering, Rice University, Houston, Texas, USA.

Tissue Engineering. Part C, Methods
|April 4, 2012
PubMed

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Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...