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Concord grape juice supplementation and neurocognitive function in human aging
Robert Krikorian1, Erin L Boespflug, David E Fleck
1Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati Academic Health Center , P.O. Box 670559, Cincinnati, Ohio 45267-0559, United States.
Journal of Agricultural and Food Chemistry
|April 4, 2012
Summary
Concord grape juice improved memory and brain activation in older adults with mild cognitive impairment. This suggests grape juice may enhance neurocognitive function and support brain health in aging populations.
Area of Science:
- Nutritional Neuroscience
- Gerontology
- Cognitive Science
Background:
- Polyphenols, particularly flavonoids in berries, are linked to cognitive benefits and improved neuronal function in aging.
- Concord grape juice is rich in polyphenols like anthocyanins and flavanols, with prior studies indicating health improvements.
- Mild cognitive impairment affects memory and cognitive function in older adults.
Purpose of the Study:
- To investigate the effects of Concord grape juice supplementation on memory function and brain activation in older adults with mild cognitive impairment.
- To assess changes in cognitive performance and neuroimaging markers after a 16-week intervention.
Main Methods:
- A randomized controlled trial involving older adults with mild cognitive impairment.
- Participants consumed either Concord grape juice or a placebo for 16 weeks.
- Memory function and brain activation were assessed using cognitive tasks and functional magnetic resonance imaging (fMRI) before and after the intervention.
Main Results:
- Grape juice consumers exhibited reduced semantic interference on memory tasks compared to the placebo group.
- Functional magnetic resonance imaging revealed greater activation in right hemisphere regions in participants consuming grape juice.
- These neuroimaging findings suggest enhanced neural processing associated with grape juice intake.
Conclusions:
- Concord grape juice supplementation can improve neurocognitive function in older adults experiencing mild memory decline.
- The study provides evidence for the beneficial effects of Concord grape juice on memory and brain activity.
- These findings support the potential of dietary interventions with Concord grape juice for supporting cognitive health in aging.
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