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Gemifloxacin.

Badraddin M H Al-Hadiya¹, Ashraf M M Mahmoud

¹Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology

|April 4, 2012

Summary

Gemifloxacin is a novel fluoroquinolone antibiotic effective against respiratory tract infections. This profile details its physicochemical properties, analytical methods, and pharmacological applications for comprehensive understanding.

Area of Science:

Pharmacology
Analytical Chemistry
Organic Chemistry

Background:

Gemifloxacin is a synthetic broad-spectrum antibacterial agent.
It is indicated for community-acquired respiratory tract infections like pneumonia.

Purpose of the Study:

To create a comprehensive profile of Gemifloxacin.
To detail its physicochemical properties, analytical methods, and pharmacological applications.

Main Methods:

Physicochemical characterization
X-ray powder diffraction
Spectroscopic analysis (UV/Vis, IR, NMR, MS)
Chromatographic techniques (TLC, GC, HPLC)
Pharmacological investigations (uses, mode of action, pharmacokinetics, toxicity)

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Main Results:

Detailed physicochemical information.
Established analytical and identification methods.
Comprehensive pharmacological data including uses, mechanism, pharmacokinetics, and toxicity.

Conclusions:

Gemifloxacin profile provides essential data for its application and further research.
The study covers synthesis, analysis, and pharmacological aspects of Gemifloxacin.