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Related Experiment Video

Updated: Apr 30, 2026

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Azithromycin.

Ahmed H H Bakheit1, Badraddin M H Al-Hadiya2, Ahmed A Abd-Elgalil3

  • 1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology
|May 6, 2014
PubMed
Summary
This summary is machine-generated.

Azithromycin, a macrolide antibiotic, inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit. This study provides a comprehensive profile of azithromycin, detailing its properties, analysis, and clinical applications.

Keywords:
Available pharmaceutical formsAzithromycinBackgroundClinical applicationsMechanism of actionMethods of preparation and analysesNomenclaturePharmacokineticsPhysico-chemical properties

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Area of Science:

  • Pharmacology
  • Microbiology
  • Medicinal Chemistry

Background:

  • Azithromycin is a macrolide antibiotic derived from erythromycin.
  • It functions by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit.

Purpose of the Study:

  • To provide a comprehensive profile of azithromycin.
  • To detail its physico-chemical properties, preparation, and analysis methods.
  • To present its clinical applications, including mechanism of action, pharmacokinetics, uses, and side effects.

Main Methods:

  • Physico-chemical characterization.
  • Development and validation of stability-indicating analytical methods (HPLC, biodiffusion assays).
  • Assessment of stability under various stress conditions (acidic, alkaline, oxidative, light, temperature, pH).

Main Results:

  • Detailed physico-chemical properties, nomenclature, and formulae.
  • Validated analytical methods for azithromycin quantification and stability assessment.
  • Comprehensive data on clinical applications, including ADME profile, efficacy, and safety.

Conclusions:

  • Azithromycin is a well-characterized antibiotic with diverse applications.
  • Validated analytical methods ensure its quality and stability.
  • The study offers a thorough resource for understanding azithromycin's pharmacology and clinical use.