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Vortioxetine: A comprehensive profile
Zubair Anwar1, Saba Sabir1, Muhammad Ali Sheraz1
1Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.
None:
Vortioxetine (VX) is a multimodal novel antidepressant drug that belongs to the class of serotonin modulators and simulators (SMS). It is widely used for the treatment of major depressive disorder (MDD). VX possesses a multimodal mechanism of action that includes inhibition of serotonin transporter (SERT) and direct modulation of serotonin receptors (i.e., 5-HT1A, 5-HT1B, 5-HT3, 5-HT1D, and 5-HT7). This monograph presents a comprehensive review that includes a description (i.e., taxonomy, nomenclature, impurities, etc.), different synthesis methods, physical characteristics (i.e., appearance, color, solubility, thermodynamic properties, etc.), methods of analysis (i.e., spectroscopic, chromatographic, electrochemical methods), stability and degradation, pharmacology (i.e., pharmacodynamics, pharmacokinetics), therapeutic uses, and adverse and toxic effects of VX.
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