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Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
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Published on: May 27, 2020

Correspondence between structure and function in the human brain at rest.

Judith M Segall1, Elena A Allen, Rex E Jung

  • 1Mind Research Network, Albuquerque, NM, USA.

Frontiers in Neuroinformatics
|April 4, 2012
PubMed
Summary
This summary is machine-generated.

This study integrates gray matter density and resting-state fMRI to map the human connectome. Gray matter

Keywords:
functionalgray matter densityindependent component analysisnetworksresting-statesource-based morphometrystructural

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Area of Science:

  • Neuroscience
  • Brain Imaging
  • Connectomics

Background:

  • Previous connectome research primarily focused on functional and structural connections, often excluding gray matter (GM) measures.
  • Functional connectivity is typically assessed using resting-state functional magnetic resonance imaging (rs-fMRI), reflecting neuronal activity.
  • Understanding the interplay between GM and functional connectivity is crucial for a comprehensive human connectome model.

Purpose of the Study:

  • To explore the spatial correspondence between gray matter density (GMD) and resting-state functional connectivity.
  • To enhance the understanding of the human connectome by integrating structural and functional brain data.
  • To investigate the role of GM in brain networks and identify potential hubs.

Main Methods:

  • Utilized structural and functional MRI data from 603 healthy participants.
  • Applied spatial independent component analysis (ICA) to both GMD maps and rs-fMRI data.
  • Compared decomposed structural and functional components using spatial correlation analysis.

Main Results:

  • Basal ganglia components showed the highest structural-to-functional spatial correlation (r = 0.59).
  • Cortical components demonstrated a general pattern of one structural component corresponding to multiple functional components.
  • The precuneus was identified as a hub in gray matter density structural network correlations.
  • Age significantly influenced structural components, while gender showed no significant effect.

Conclusions:

  • Integrating gray matter density with functional connectivity provides valuable insights into the human connectome.
  • The findings highlight specific structural-functional correspondences, particularly in the basal ganglia and cortex.
  • The precuneus emerges as a key structural hub, and age is a significant modulator of brain structure networks.