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Updated: Jun 9, 2026

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IntegriLAB: a blockchain-enabled electronic lab notebook for reproducible neuroimaging research.

Rubaida Easmin1, Mattia Veronese1,2, Paul Allen1,3

  • 1Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Frontiers in Neuroinformatics
|June 8, 2026
PubMed
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This study introduces IntegriLAB, a novel Electronic Lab Notebook (ELN) framework. It enhances research reproducibility and trust by centralizing data, code, and documentation with blockchain-verified auditability.

Area of Science:

  • Data-intensive scientific research
  • Neuroimaging analysis workflows
  • Scientific reproducibility and data integrity

Background:

  • Managing complex research data, scripts, and documentation is challenging, especially in neuroimaging.
  • Existing Electronic Lab Notebooks (ELNs) often lack interoperability, authorship certification, and immutable audit trails.
  • Fragmented tools and poor integration hinder reproducibility in scientific research.

Purpose of the Study:

  • To propose a novel Electronic Lab Notebook (ELN) framework, IntegriLAB, for end-to-end research process tracking.
  • To address the limitations of current ELNs in terms of interoperability, authorship certification, and auditability.
  • To enhance trust and reproducibility in data-intensive scientific fields.

Main Methods:

Keywords:
blockchain verificationdata integrityelectronic lab notebookneuroimagingresearch reproducibility

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Last Updated: Jun 9, 2026

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  • Developed a centralized, web-based ELN framework (IntegriLAB) integrating data, document, and code repositories.
  • Integrated existing tools like DataLad, Overleaf, and GitHub for a proof-of-concept case study.
  • Utilized LabTrace, a green blockchain technology, for cryptographically signing and immutably recording research activities.

    • Main Results:

    • IntegriLAB successfully consolidates diverse research components into a unified system.
    • The framework enables real-time monitoring of the research cycle while maintaining familiar user workflows.
    • LabTrace provides immutable, cryptographically signed records, ensuring data integrity and verifiable authorship.

    Conclusions:

    • IntegriLAB advances research reproducibility by unifying project management and secure data handling.
    • The blockchain-based verification system fosters trust and strengthens collaborative research practices.
    • This novel ELN framework offers a scalable solution for managing complex, data-intensive research projects.