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Crescentic glomerulonephritis in IgA multiple myeloma: a case report
Grace T Moscoso-Solorzano1, Marcus V Madureira-Silva, Carlos Balda
1Glomerulopathy Section, Universidade Federal de São Paulo, São Paulo, Brazil.
Nephron Extra
|April 4, 2012
Summary
Rapidly progressive glomerulonephritis (GN) with crescents can signal a hidden IgA multiple myeloma (MM). This rare presentation highlights the importance of thorough investigation for B-cell dyscrasias in kidney disease.
Area of Science:
- Nephrology
- Hematology
- Oncology
Background:
- Glomerulonephritis (GN) with crescents and rapid progression is uncommon.
- Few cases link this presentation to an unsuspected B-cell dyscrasia.
Observation:
- A patient presented with rapidly progressive GN, initially without a clear cause.
- Renal biopsy revealed diffuse proliferative and exudative GN with significant plasma cell infiltration.
Findings:
- The patient was diagnosed with IgA multiple myeloma (MM) during the workup for GN.
- This suggests a potential link between proliferative GN with crescents and MM.
Implications:
- This case highlights a rare presentation of multiple myeloma.
- It underscores the need to consider hematologic malignancies in unexplained rapidly progressive GN.
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