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Related Experiment Video

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Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development
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Response surface methodology and process optimization of sustained release pellets using Taguchi orthogonal array

Gurinder Singh1, Roopa S Pai, V Kusum Devi

  • 1Department of Pharmaceutics, Faculty of Pharmacy, Al-Ameen College of Pharmacy, Bangalore, Karnataka, India.

Journal of Advanced Pharmaceutical Technology & Research
|April 4, 2012
PubMed
Summary

Sustained-release furosemide pellets were developed to improve oral bioavailability. Optimized extrusion/spheronization techniques resulted in pellets with significant sustained-release characteristics compared to the pure drug.

Keywords:
Central composite designTaguchi orthogonal array designextrusion/spheronizationfurosemidestatistical analysis

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Pharmacokinetics

Background:

  • Furosemide, a diuretic and antihypertensive, exhibits low oral bioavailability due to first-pass metabolism and a short half-life.
  • Developing sustained-release (SR) formulations is crucial to overcome these pharmacokinetic limitations.

Purpose of the Study:

  • To formulate and evaluate sustained-release (SR) furosemide pellets for oral administration.
  • To optimize pelletization process parameters using Design of Experiments (DOE) and response surface methodology (RSM).

Main Methods:

  • Pellets were prepared using extrusion/spheronization with Drug Coat L-100 and microcrystalline cellulose.
  • A 3(2) central composite design was employed for systematic optimization of process parameters.
  • In vitro dissolution studies were conducted using USP apparatus Type I in simulated gastric and intestinal pH.

Main Results:

  • Optimized formulation achieved significant sustained-release characteristics.
  • Statistical analysis (paired t test, ANOVA) showed significant differences in dissolution profiles compared to pure furosemide and commercial products.
  • Process optimization demonstrated high prognostic ability for developing effective SR pellets.

Conclusions:

  • The study successfully developed optimized process parameters for furosemide SR pellets.
  • The developed pellets exhibit significant sustained-release properties, addressing the limitations of conventional furosemide formulations.
  • This approach offers a promising strategy for enhancing furosemide's oral delivery and therapeutic efficacy.