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Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT
Published on: April 1, 2019
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Recent advances in human brown fat physiology
D V Muralidhara1, Krithika D Muralidhara
1Department of Physiology, Faculty of Medicine and Health Sciences, University Sultan Zainal Abidin, Kuala Terengganu, Malaysia. diviem@yahoo.com
Indian Journal of Physiology and Pharmacology
|April 5, 2012
Summary
Brown fat, unlike white fat, burns energy into heat, aiding thermoregulation and potentially treating obesity. Recent research confirms its presence and therapeutic potential in adult humans.
Area of Science:
- Adipose tissue biology
- Metabolic regulation
- Obesity research
Background:
- White adipose tissue stores lipids and expands pathologically in obesity.
- Brown adipose tissue generates heat by burning energy, crucial for thermoregulation.
Purpose of the Study:
- To explore the role of brown adipose tissue in energy balance and thermoregulation.
- To investigate the recent evidence for the presence and function of brown fat in adult humans.
- To assess the potential of brown fat as a therapeutic target for obesity.
Main Methods:
- Review of recent scientific literature and research findings.
- Analysis of new techniques supporting brown fat existence in adults.
- Examination of secreted chemicals from adipose tissues involved in weight control.
Main Results:
- Brown fat actively burns energy to produce heat via a unique metabolic pathway.
- Recent advancements confirm the active presence of brown fat in adult humans.
- Adipose tissues secrete chemicals that significantly influence body weight regulation.
Conclusions:
- Brown fat plays a vital role in thermoregulation and energy expenditure.
- The discovery of active brown fat in adults opens new avenues for obesity treatment.
- Targeting brown fat may offer promising therapeutic strategies for metabolic disorders.

