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CD28-specific immunomodulating antibodies: what can be learned from experimental models?

N Poirier1, G Blancho, B Vanhove

  • 1Institut National de la Santé Et de la Recherche Médicale, Unité Mixte de Recherche 1064, Nantes, France.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|April 5, 2012
PubMed
Summary

Inducing tolerance to alloantigens is difficult. Targeting CD28 molecules offers a promising strategy for immune tolerance in transplantation and autoimmune diseases, distinct from targeting B7 counterparts.

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Area of Science:

  • Immunology
  • Transplant Immunology
  • Immunotherapy

Background:

  • Alloantigen tolerance is a key challenge in transplantation.
  • Conventional immunosuppression non-specifically inhibits the immune system.
  • CD28 family costimulatory molecules are crucial for immune responses and peripheral tolerance.

Purpose of the Study:

  • To review the role of costimulatory molecules in immune tolerance.
  • To highlight the differences between targeting CD28 molecules and B7 counterparts.
  • To discuss CD28-specific immunomodulating strategies in transplantation and autoimmune diseases.

Main Methods:

  • Review of recent discoveries in costimulatory interactions.
  • Analysis of the B7:CD28 family "quintet" (CD28/B7/CTLA-4/PD-L1/ICOSL).
  • Evaluation of experimental models of transplantation and autoimmune diseases.

Main Results:

  • Novel costimulatory interactions necessitate a revised view of immunoregulatory pathways.
  • Targeting CD28 molecules offers distinct therapeutic advantages over targeting B7 counterparts.
  • CD28-specific strategies show promise in experimental models.

Conclusions:

  • Understanding complex costimulatory pathways is vital for treating immunological diseases.
  • Selective targeting of CD28 molecules presents a promising immunomodulatory strategy.
  • CD28-specific approaches offer a refined alternative to conventional immunosuppression.