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A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
Published on: January 12, 2017
Serum trace element levels in patients with bladder cancer
Ilhan Gecit1, Servet Kavak, Halit Demir
1Department of Urology, Division of Biochemistry, Yuzuncu Yil University, Van, Turkey. ilhan_gecit@hotmail.com
Asian Pacific Journal of Cancer Prevention : APJCP
|April 5, 2012
Summary
Serum trace element levels differ in bladder cancer patients. Cadmium, nickel, and cobalt were higher, while manganese and zinc were lower, suggesting a link to bladder cancer development.
Area of Science:
- Environmental Science
- Biochemistry
- Oncology
Background:
- Trace elements are vital for biological functions but can become toxic at elevated levels.
- Understanding trace element dysregulation is crucial for identifying disease biomarkers and potential causes.
Purpose of the Study:
- To investigate the association between serum trace element levels and bladder cancer.
- To compare trace element profiles in bladder cancer patients versus healthy controls.
Main Methods:
- Utilized furnace atomic absorption spectrophotometry for precise trace element quantification.
- Analyzed serum samples from 35 bladder cancer patients and 34 healthy volunteers.
Main Results:
- Significantly elevated serum levels of cadmium (Cd), nickel (Ni), and cobalt (Co) were observed in bladder cancer patients (p<0.05).
- Significantly decreased serum levels of manganese (Mn) and zinc (Zn) were found in bladder cancer patients (p<0.05).
Conclusions:
- A potential relationship exists between altered serum trace element levels and bladder cancer occurrence.
- Increased Cd, Ni, Co and decreased Zn, Mn may contribute to bladder cancer development.
- Further prospective studies are required to establish a definitive cause-and-effect relationship.
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