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Topical timolol for small hemangiomas of infancy
Matthias Moehrle1, Christine Léauté-Labrèze, Verena Schmidt
1Department of Dermatology, University Hospital, Tuebingen, Germany. moehrle@med.uni-tuebingen.de
Pediatric Dermatology
|April 5, 2012
Summary
Topical timolol gel offers a promising alternative for treating infantile hemangiomas, inhibiting growth and promoting regression. This non-selective beta-blocker may provide a safer option compared to systemic propranolol.
Area of Science:
- Dermatology
- Pediatric Medicine
- Pharmacology
Background:
- Systemic propranolol is a common treatment for infantile hemangiomas but raises safety concerns.
- Infantile hemangiomas are benign vascular tumors affecting infants, requiring effective treatment options.
Observation:
- A case series evaluated the efficacy of topical timolol gel for infantile hemangiomas.
- Eleven hemangiomas in nine children, including preterm infants, were treated with a compounded timolol gel (0.5%).
- Application involved a standardized occlusive dressing delivering approximately 0.25 mg of timolol.
Findings:
- Topical timolol demonstrated growth arrest, reduced redness, and decreased thickness within two weeks.
- Significant regression was observed, with seven hemangiomas resolving almost completely.
- Regression occurred earlier than spontaneous resolution, which typically starts at 9-12 months.
Implications:
- Topical timolol presents a potentially safer alternative to systemic propranolol for infantile hemangiomas.
- Further research, including prospective randomized trials, is needed to confirm optimal dosage, duration, and application methods.
- This approach may offer a valuable non-invasive treatment for infantile hemangiomas.
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