Related Experiment Video

Updated: May 23, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Long-term antihypertensive efficacy of losartan/hydrochlorothiazide combination therapy on home blood pressure

Sonoko Miyagawa1, Hiroyuki Yamada, Hiroaki Matsubara

  • 1Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kyoto, Japan.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|April 5, 2012
PubMed

Insights

Losartan/hydrochlorothiazide combination therapy effectively lowers both home and clinic blood pressure long-term in hypertensive patients. Younger individuals experienced greater home blood pressure reductions compared to older patients.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Angiotensin receptor blocker (ARB)/hydrochlorothiazide (HCTZ) combination therapy shows prompt clinic blood pressure (BP) reduction.
  • Long-term home BP efficacy of ARB/HCTZ is not fully established.

Purpose of the Study:

  • To investigate the 1-year antihypertensive efficacy of fixed-dose losartan (50 mg)/HCTZ (12.5 mg) combination therapy on home and clinic BP.
  • To compare efficacy in younger versus elderly hypertensive patients.

Main Methods:

  • Open-label, multicenter observational study.
  • 151 hypertensive patients uncontrolled on ARB regimens were switched to losartan/HCTZ.
  • Home and clinic BP measurements were taken at baseline, 3 months, and 12 months.

Main Results:

  • Losartan/HCTZ significantly reduced mean home BP (153/85 to 136/77 mm Hg) and clinic BP (158/87 to 136/77 mm Hg) after 3 months (P < .001).
  • These reductions were maintained at 12 months.
  • Younger patients (<65 years) showed a greater home BP reduction than elderly patients (≥65 years).

Conclusions:

  • Losartan/HCTZ combination therapy demonstrates 1-year long-term efficacy for both home and clinic blood pressure.
  • Antihypertensive efficacy on home BP is more pronounced in younger patients uncontrolled on ARB monotherapy.

Related Concept Videos

Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

Antihypertensive Drugs: Angiotensin II Receptor Blockers

In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...