Enterococcus avium. An unusual cause of cerebral abscess

Abimbola O Osoba1, Hussam Kutub, Ahmed Waliuddin

  • 1Division of Microbiology, King Khalid National Guard Hospital, PO Box 9515, Jeddah 21423, Kingdom of Saudi Arabia. Tel. +966 (2) 624000. Fax. +966 (2) 6247444.

Insights

Enterococcus avium, a rare bacterium, caused a cerebral abscess in a young woman after brain tumor treatment. Prompt antibiotic therapy led to successful recovery, highlighting this organism

Area of Science:

  • Infectious Diseases
  • Neurology
  • Microbiology

Background:

  • Enterococci are common human flora but increasingly cause infections.
  • Enterococcus avium is an uncommon human pathogen.
  • Cerebral abscesses are serious complications, often bacterial.

Purpose of the Study:

  • To report a rare case of cerebral abscess caused by Enterococcus avium.
  • To discuss the pathogenesis of Enterococcus avium in brain infections.
  • To highlight successful treatment outcomes for this rare infection.

Main Methods:

  • Case report of a 19-year-old female with astrocytoma.
  • Diagnosis of cerebral abscess post-chemotherapy and radiotherapy.
  • Identification of Enterococcus avium from abscess pus via culture.
  • Successful treatment with antibiotics and surgical drainage.

Main Results:

  • Enterococcus avium was identified as the causative agent of a cerebral abscess.
  • The patient, previously treated for astrocytoma, recovered fully after treatment.
  • This case underscores the potential of Enterococcus avium as a pathogen in immunocompromised individuals.

Conclusions:

  • Enterococcus avium can cause severe infections like cerebral abscesses, albeit rarely.
  • Early diagnosis and appropriate antibiotic treatment are crucial for favorable outcomes.
  • Further research into the pathogenesis of Enterococcus avium is warranted.

Related Concept Videos

Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Cerebral Edema l: Introduction01:19

Cerebral Edema l: Introduction

Cerebral edema is a pathological increase in brain water content that disrupts intracranial pressure regulation and impairs neurological function. Because the cranial vault is rigid, even modest increases in tissue volume can compromise cerebral perfusion, distort neural structures, and initiate secondary injury. Cerebral edema develops through four principal mechanisms: vasogenic, cytotoxic, interstitial, and ionic.Vasogenic EdemaVasogenic edema arises from disruption of the blood–brain...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...