A novel anticancer diterpenoid from Jatropha gossypifolia
Abiodun Falodun1, Udo Kragl, Serge-Mitherand Tengho Touem
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria, Edo State 30001. faloabi@uniben.edu
Natural Product Communications
|April 6, 2012
Abstract:
Jatropha gossypifolia root bark is used in ethnomedicine for bacterial infections and cancer of the lungs. Phytochemical investigation resulted in the isolation and characterization of a potent anticancer and novel lathyrane diterpenoid compound, abiodone, with an unusual methylene group. The structure of this novel compound was established by 1D, and 2D NMR spectroscopic experiments a nd confirmed by X-ray analysis.
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