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Malignant transformation of retroperitoneal inflammatory pseudotumor to undifferentiated high-grade pleomorphic

Linh Ho1, Sindu Sheth, Heidi Wassef

  • 1Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. linhho@usc.edu

Clinical Nuclear Medicine
|April 6, 2012
PubMed

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Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...