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Enamel lesion parameter correlations between polychromatic micro-CT and TMR.

H Hamba¹, T Nikaido, A Sadr

¹Cariology and Operative Dentistry, Department of Restorative Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Journal of Dental Research

|April 6, 2012

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Micro-computed tomography (µCT) offers non-destructive enamel lesion analysis. This study validates µCT against the gold standard Transverse Microradiography (TMR), finding µCT comparable for lesion depth and mineral loss evaluation.

Area of Science:

Dental Research
Biomaterials Science
Imaging Technology

Background:

Transverse microradiography (TMR) is the gold standard for evaluating enamel demineralization.
Micro-computed tomography (µCT) offers non-destructive analysis but suffers from beam-hardening artifacts.
No prior studies have validated µCT against TMR for enamel lesion assessment.

Purpose of the Study:

To validate micro-computed tomography (µCT) measurements of enamel lesions against Transverse Microradiography (TMR).
To assess the impact of various X-ray conditions and beam-hardening correction (BHC) on µCT accuracy.
To establish µCT as a reliable, non-destructive alternative to TMR for enamel lesion studies.

Main Methods:

Human molars with natural white-spot lesions were scanned using µCT under different kV, µA, filter (Al, Al/Cu), and BHC settings.

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Grayscale values from µCT were converted to mineral density using phantoms.

Thin sections of the same lesions were analyzed using TMR for comparison.

Main Results:

µCT measurements of lesion depth (LD) and mineral loss (ΔZ) showed strong correlations with TMR (r > 0.86, p < 0.001) across most tested conditions.
The combination of Al/Cu filters effectively reduced beam-hardening effects, even without software BHC.
µCT analysis without BHC using only an Al filter showed no significant correlation with TMR.

Conclusions:

Micro-computed tomography (µCT) is a validated, non-destructive alternative to Transverse Microradiography (TMR) for quantifying enamel lesions.
Optimized X-ray filtering (Al/Cu) and BHC are crucial for accurate µCT assessment of demineralization.
µCT provides comparable results to TMR, enabling longitudinal, non-destructive studies of enamel caries.