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Histoplasmosis: update 1989.

S F Davies1

  • 1Department of Medicine, Hennepin County Medical Center, Minnesota, Minneapolis 55415.

Seminars in Respiratory Infections
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

Histoplasmosis, once thought rare, is a common fungal infection, particularly in the central US. Recognition of its widespread, often mild nature has revealed diverse clinical presentations and complications.

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Public Health

Background:

  • Histoplasmosis was historically considered a rare, fatal disease.
  • Widespread skin testing in the 1940s revealed it as a common, usually benign infection in the central United States.
  • Subclinical and mildly symptomatic cases were previously undiagnosed, leading to an underestimation of its prevalence.

Purpose of the Study:

  • To review the history of histoplasmosis.
  • To outline current understanding of its epidemiology, pathogenesis, clinical features, diagnosis, and treatment.
  • To highlight recent advancements in the field.

Main Methods:

  • Historical review of histoplasmosis literature.
  • Analysis of epidemiological data.

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  • Synthesis of current clinical and diagnostic concepts.

    • Main Results:

    • Histoplasmosis is a common infection, often asymptomatic or mild, particularly in the central US.
    • Recognized clinical forms include diffuse infiltrates, chronic cavitary disease, mediastinal granuloma, and superior vena cava syndrome.
    • Despite its long history, histoplasmosis continues to present new challenges and requires ongoing research.

    Conclusions:

    • Histoplasmosis is a prevalent, multifaceted infection with a spectrum of clinical manifestations.
    • Understanding its epidemiology and diverse presentations is crucial for accurate diagnosis and management.
    • Continued research is necessary to address emerging aspects of this fungal disease.