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Biologically active C-alkylated flavonoids from Dodonaea viscosa
Akhtar Muhammad1, Itrat Anis, Ajmal Khan
1Department of Chemistry, University of Karachi, Karachi 75270, Pakistan.
Archives of Pharmacal Research
|April 6, 2012
Summary
Five C-alkylated flavonoids were isolated from Dodonaea viscosa, showing mild urease inhibition but no significant effect on alpha-chymotrypsin enzyme activity.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Enzymology
Background:
- Dodonaea viscosa is a plant species known for its diverse secondary metabolites.
- Flavonoids, a class of plant compounds, possess a wide range of biological activities.
- C-alkylated flavonoids represent a specific subclass with unique structural features.
Purpose of the Study:
- To isolate and characterize C-alkylated flavonoids from the aerial parts of Dodonaea viscosa.
- To evaluate the inhibitory potential of these isolated compounds against urease and alpha-chymotrypsin enzymes.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation employing 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy and mass spectrometry.
- Enzyme inhibition assays for urease and alpha-chymotrypsin.
Main Results:
- Five C-alkylated flavonoids, including one new compound (1), were successfully isolated and identified.
- Compounds 1-5 demonstrated mild inhibitory activity against the urease enzyme.
- No significant inhibitory effects were observed for compounds 1-5 against alpha-chymotrypsin.
Conclusions:
- The aerial parts of Dodonaea viscosa are a source of novel and known C-alkylated flavonoids.
- These isolated flavonoids exhibit weak urease inhibitory properties.
- Further research may be warranted to explore other potential bioactivities or structural modifications of these compounds.
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