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Updated: May 23, 2026
08:23
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
Atherosclerosis in sickle cell disease - a review
Mohamed A Elsharawy1, Khaled M Moghazy, Mohamed A Shawarby
1Departments of Surgery;
Summary
Sickle cell disease (SCD) patients experience atherosclerosis due to endothelial dysfunction, homocysteine, and platelets. This review covers its pathogenesis, sites, assessment, and treatments.
Area of Science:
- Cardiovascular Science
- Hematology
- Pathology
Background:
- Sickle cell disease (SCD) is characterized by acute vaso-occlusive crises.
- Atherosclerosis development is increasingly recognized in SCD patients.
Purpose of the Study:
- To review the pathogenesis of atherosclerosis in SCD.
- To describe common and uncommon sites of atherosclerosis.
- To discuss radiological assessment and therapeutic strategies.
Main Methods:
- Review of current literature on SCD and atherosclerosis.
- Analysis of the roles of endothelial dysfunction, homocysteine, and platelets.
- Evaluation of radiological findings and treatment options.
Main Results:
- Endothelial dysfunction, elevated homocysteine, and platelet activation are key contributors to atherosclerosis in SCD.
- Atherosclerosis affects various vascular beds in SCD patients.
- Radiological assessment aids in identifying and monitoring atherosclerosis.
Conclusions:
- Understanding atherosclerosis pathogenesis in SCD is crucial for management.
- Targeting endothelial dysfunction, homocysteine, and platelets may offer therapeutic benefits.
- Multifaceted approaches are needed for treating atherosclerosis in SCD patients.
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