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Updated: Jan 29, 2026
Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
Published on: February 19, 2022
Gastrointestinal stromal tumors. A clinicopathological study
Hanan M Alghamdi1, Samir S Amr, Mohamed A Shawarby
1Department of Surgery, College of Medicine, King Fahad Hospital of the University, University of Imam Abdurahman Bin Faisal, Al Khobar, Kingdom of Saudi Arabia. E-mail. hmalghamdi@uod.edu.sa.
This study analyzed gastrointestinal stromal tumors (GISTs) in 36 patients, finding similarities to international data but with minor differences in clinical presentation and immunohistochemistry (IHC) markers. Key findings include stomach as the most common site and abdominal pain as a frequent symptom.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract.
- Understanding their clinical and immunohistochemical (IHC) profiles is crucial for diagnosis and treatment.
Purpose of the Study:
- To evaluate the clinical characteristics and IHC properties of GISTs.
- To compare these findings with existing international data.
Main Methods:
- Retrospective analysis of 36 GIST patients diagnosed between 1997 and 2015.
- Prospective immunohistochemical staining for various markers.
- Data collected from two tertiary hospitals.
Main Results:
- Median patient age was 54 years, with a female predominance (1:1.7 male to female ratio).
- Stomach (63.8%) was the most common site, followed by the small bowel (25%).
- Abdominal pain (33.3%) and GI bleeding (30.5%) were the most frequent symptoms. Gastric GISTs were often early-stage, while non-gastric GISTs were advanced. IHC showed high positivity for vimentin (88.9%) and CD117 (83.3%).
Conclusions:
- GISTs in this cohort share major similarities with international data.
- Minor variations in clinical presentation and IHC profiles were observed compared to global trends.
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