Related Experiment Video
Updated: May 23, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
[Aging and the control of the insulin-FOXO signaling pathway]
1Département de génétique, Stanford University, 94305 Stanford, CA, États-Unis. abrunet1@stanford.edu
Abstract:
Aging is a complex process that is accompanied by the onset of a series of age-related diseases, including Alzheimer's disease. Aging is controlled by a combination of genetic and environmental factors. Among the genes that regulate aging, the insulin-FOXO signaling pathway plays a central role, as this pathway regulates lifespan in multiple species, such as worms, flies, and mice. In humans, exceptional longevity - being a centenarian - is also associated with genetic variation in this insulin-FOXO pathway. Recent evidence indicates that the FOXO family of transcription factors plays a key role in the self-renewal of adult and embryonic stem cells, which could contribute to tissue regeneration. Understanding the mechanisms underlying aging should help better prevent and treat age-dependent diseases.
Related Concept Videos
Insulin: The Receptor and Signaling Pathways
The Effect of Aging on Tissues
PI3K/mTOR/AKT Signaling Pathway
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Type II Diabetes II: Pathophysiology
Type I Diabetes II: Pathophysiology
