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Components of left ventricular ejection and filling in patients with aortic regurgitation assessed by

Vaida Mizarienė1, Silvija Bučytė, Diana Zaliaduonytė-Pekšienė

  • 1Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Eivenių 2, 50028 Kaunas, Lithuania. vaidamizariene@gmail.com.

Medicina (Kaunas, Lithuania)
|April 7, 2012
PubMed

Insights

Speckle-tracking echocardiography reveals left ventricular (LV) long-axis dysfunction and increased apical rotation in moderate aortic regurgitation (AR). Severe AR shows reduced LV radial function and basal rotation, impacting LV diastolic filling.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Mechanics

Background:

  • Aortic regurgitation (AR) can lead to left ventricular (LV) remodeling and dysfunction.
  • Assessing LV function in AR patients is crucial for management.
  • Speckle-tracking echocardiography offers advanced methods to evaluate LV mechanics.

Purpose of the Study:

  • To evaluate LV longitudinal, radial, and rotational function in patients with moderate and severe aortic regurgitation (AR).
  • To explore the relationship between these mechanical parameters and conventional LV systolic and diastolic function metrics.
  • To identify predictors of LV ejection fraction and diastolic filling in AR patients.

Main Methods:

  • Speckle-tracking echocardiography was used to measure LV longitudinal, radial, and rotational strain and strain rate.
  • Asymptomatic patients with moderate AR (26), severe AR (34), and healthy controls (28) were included.
  • Offline analysis of LV mechanics was performed.

Main Results:

  • Moderate AR showed reduced systolic longitudinal strain and strain rate, with increased apical rotation and rotation rate compared to controls.
  • Severe AR demonstrated reduced LV systolic basal rotation, systolic radial strain, and diastolic radial strain rate versus controls.
  • Global longitudinal/radial strain and LV systolic diameter predicted LV ejection fraction; LV basal rotation, diastolic longitudinal strain rate, and systolic longitudinal strain predicted LV diastolic filling.

Conclusions:

  • LV long-axis dysfunction with increased apical rotation characterizes moderate AR.
  • Reduced LV radial function and systolic basal rotation are observed in severe AR.
  • LV diastolic filling is influenced by both systolic and diastolic LV strain and rotation components in AR.

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