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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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Myocarditis: Differences in Clinical Expression between Patients with ST-Segment Elevation in Electrocardiogram vs.

Grytė Ramantauskaitė1, Kingsley A Okeke2, Vaida Mizarienė1

  • 1Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.

Journal of Personalized Medicine
|October 25, 2024
PubMed

Insights

ST-segment elevation (STE) in myocarditis cases indicates more severe myocardial damage, evidenced by higher C-reactive protein (CRP) and lower left ventricular ejection fraction (LVEF). Despite this, myocarditis generally shows a favorable prognosis with treatment.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Biomarker Research

Background:

  • Myocarditis can present with electrocardiogram (ECG) patterns mimicking ST-segment elevation myocardial infarction (STEMI) or non-STEMI.
  • The clinical significance of ST-segment elevation (STE) in myocarditis, particularly regarding myocardial damage and severity, remains unclear.

Purpose of the Study:

  • To investigate the association between ST-segment elevation (STE) patterns on ECG and myocardial damage in patients with myocarditis.
  • To compare clinical, laboratory, and instrumental findings between myocarditis patients with and without STE patterns.

Main Methods:

  • Retrospective study of 38 hospitalized myocarditis patients.
  • Patients classified into two groups: ST-segment elevation (STE) (n=25) and non-STE (n=13).
  • Analysis of epidemiological, laboratory (CRP, Troponin I), and echocardiographic (LVEF, LV strain) data.

Main Results:

  • The STE group exhibited significantly higher C-reactive protein (CRP) levels (103.40 vs. 43.54 mg/L).
  • The non-STE group showed a higher left ventricular ejection fraction (LVEF) (56.58% vs. 49.71%).
  • Lower LVEF correlated with higher Troponin I (TnI) and CRP levels; lower LV strain correlated with higher TnI.

Conclusions:

  • ST-segment elevation (STE) in myocarditis is associated with elevated CRP and reduced LVEF, suggesting more significant myocardial injury.
  • Higher TnI and CRP levels correlate with worse left ventricular function.
  • Myocarditis demonstrates a favorable prognosis based on 6-month echocardiographic follow-up.
Abstract

Keywords:
ST-segment elevationechocardiographyelectrocardiogrammyocarditis

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