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Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications
Björn Meermann1, Michael Sperling
1Institute of Inorganic and Analytical Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstr. 30, 48149 Münster, Germany. meermann@bafg.de
Analytical and Bioanalytical Chemistry
|April 7, 2012
Summary
This review covers hyphenated techniques for metal-based drug speciation analysis. Combining elemental and molecular detection offers powerful insights into drug metabolites in biological samples.
Area of Science:
- Analytical Chemistry
- Pharmacology
Background:
- Speciation analysis of metal-based pharmaceuticals is crucial for understanding their behavior and efficacy.
- Hyphenated techniques are essential tools for complex analytical challenges in pharmaceutical analysis.
Purpose of the Study:
- To review method development and applications of hyphenated techniques for metal-based pharmaceutical speciation.
- To discuss the advantages and limitations of various separation and detection modes.
Main Methods:
- High-performance liquid chromatography (HPLC)
- Capillary electrophoresis (CE)
- Gas chromatography (GC)
- Inductively coupled plasma-mass spectrometry (ICP-MS)
- Electrospray ionization-mass spectrometry (ESI-MS)
Main Results:
- ICP-MS is advantageous for quantifying metal-containing drugs and heteroatoms, offering species-independent sensitivity and multielement capabilities.
- ESI-MS complements ICP-MS by providing molecular information lost in ICP-MS analysis.
- Combined elemental and molecular speciation analysis is powerful for metal-based pharmaceuticals and metabolites.
Conclusions:
- Hyphenated techniques, particularly ICP-MS and ESI-MS, are powerful tools for the speciation analysis of metal-based pharmaceuticals.
- The combination of elemental and molecular information enables comprehensive analysis of drugs and their metabolites in various matrices.
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