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Updated: May 23, 2026

Morphometric Analyses of Retinal Sections
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Quantitative analysis of myopic chorioretinal degeneration using a novel computer software program.

Kumari Neelam1, Rebecca Y K Chew, Martin H K Kwan

  • 1Department of Ophthalmology and Visual Sciences, Khoo Teck Puat Hospital, 90 Yishun Central, Singapore, 768828, Singapore.

International Ophthalmology
|April 7, 2012
PubMed
Summary

A new computer program quantifies myopic chorioretinal degeneration (MCDI) using fundus photos. Older myopic individuals with higher MCDI and longer axial length are at increased risk for vision complications.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Computational Biology

Background:

  • Myopic chorioretinal degeneration is a significant cause of vision impairment.
  • Current assessment methods for myopic degeneration can be subjective.
  • Objective quantification is needed for better risk stratification.

Purpose of the Study:

  • To develop and validate a novel computer software program for quantifying fundus color as a surrogate for myopic chorioretinal degeneration (MCDI).
  • To assess the relationship between MCDI and demographic/ocular parameters in myopic subjects.

Main Methods:

  • A cross-sectional study involving 152 eyes of 78 myopic subjects.
  • Data collected included visual acuity, refractive status, ocular biometrics, intraocular pressure, and color fundus photography.

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  • Myopic chorioretinal degeneration index (MCDI) was calculated using an automated computer program.

    • Main Results:

    • Older subjects (≥40 years) exhibited significantly higher MCDI compared to younger subjects (<40 years).
    • MCDI showed a significant positive correlation with axial length (r=0.47) and lens thickness (r=0.26).
    • A significant positive relationship was found between MCDI and visual acuity (r=0.30).

    Conclusions:

    • The novel computer program provides an objective method for assessing chorioretinal degenerative changes in myopia.
    • Older myopic individuals with higher MCDI and longer axial lengths represent a high-risk group for myopia-related visual complications.