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Is cohesin required for spindle-pole-body/centrosome cohesion?
Hui Jin1, Martin Avey, Hong-Guo Yu
1Department of Biological Science; The Florida State University; Tallahassee, FL USA.
Communicative & Integrative Biology
|April 7, 2012
Summary
Cohesin may indirectly regulate budding yeast centrosome duplication and separation. Antagonistic Aurora and Polo kinases likely coordinate this process with chromosome segregation during meiosis.
Area of Science:
- Cell Biology
- Molecular Biology
- Genetics
Background:
- Centrosomes act as microtubule-organizing centers crucial for cell division.
- In budding yeast, the spindle pole body (SPB) shares components with animal centrioles.
- Centrosome duplication parallels DNA replication, with linked centrosomes separating for bipolar spindle formation.
Purpose of the Study:
- To explore the potential role of cohesin in spindle pole body cohesion during yeast meiosis.
- To investigate the mechanisms coordinating chromosome segregation with centrosome cohesion and duplication.
Main Methods:
- Literature review and discussion of recent findings on cohesin localization and function in centrosomes.
- Analysis of the interplay between Aurora kinase and Polo kinase in centrosome regulation.
- Comparative analysis of centrosome cohesion mechanisms in yeast and animal cells.
Main Results:
- Cohesin is localized to animal centrosomes and may engage paired centrioles.
- The study proposes that cohesin's role in budding yeast centrosome regulation is indirect.
- Antagonistic interactions between Aurora and Polo kinases are hypothesized to mediate coordination.
Conclusions:
- The coordination of chromosome segregation and centrosome dynamics during yeast meiosis is likely regulated by Aurora and Polo kinases.
- Cohesin's involvement in budding yeast centrosome regulation appears to be indirect, contrasting with potential direct roles in animal cells.
Related Concept Videos
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Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of homologous...
Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of homologous...
02:20Cohesins
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Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of homologous...
Cohesin complexes in Meiotic Division
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In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a microtubule array...
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02:57Attachment of Sister Chromatids
As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules. Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall of a...