Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Replisome03:01

The Replisome

DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with the...
The Replisome03:01

The Replisome

DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with the...
Replication in Eukaryotes02:31

Replication in Eukaryotes

Overview
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes02:31

Replication in Eukaryotes

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phosphatidylinositol diphosphate binding by ESCRT-III filaments.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Lenacapavir allosterically remodels the HIV-1 capsid.

bioRxiv : the preprint server for biology·2026
Same author

RNA splicing is required for timely completion of abscission and is modulated by the abscission checkpoint.

bioRxiv : the preprint server for biology·2025
Same author

T cell ectosomes promote antibody responses through cognate TCR-pMHC interactions.

bioRxiv : the preprint server for biology·2025
Same author

Thylakoid membrane remodeling by VIPP1 ESCRT-III-like filaments.

Nature structural & molecular biology·2025
Same author

Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing.

PLoS pathogens·2025
Same journal

Combination adjuvants: clinical value and mechanisms of action.

Current opinion in virology·2026
Same journal

Editorial Overview: Immunopathogenesis in viral disease.

Current opinion in virology·2026
Same journal

Architecture and evolution of viral complement evasion.

Current opinion in virology·2026
Same journal

The HEV capsid through a dynamic lens: parallels and divergence from caliciviruses.

Current opinion in virology·2026
Same journal

When structural rationales fall short: revisiting the immunogenicity of herpesvirus prefusion and postfusion glycoprotein B.

Current opinion in virology·2026
Same journal

Beyond brain fog: viral proteins as convergent drivers of neuroinflammation and proteinopathy.

Current opinion in virology·2026
See all related articles

Related Experiment Video

Updated: May 23, 2026

Hybrid Ensemble and Single-molecule Assay to Image the Motion of Fully Reconstituted CMG
10:11

Hybrid Ensemble and Single-molecule Assay to Image the Motion of Fully Reconstituted CMG

Published on: July 26, 2024

Assemble, replicate, remodel and evade

Wesley I Sundquist, Robert M Krug

    Current Opinion in Virology
    |April 10, 2012
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion
    07:37

    CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion

    Published on: June 25, 2017

    Origami Inspired Self-assembly of Patterned and Reconfigurable Particles
    12:33

    Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

    Published on: February 4, 2013

    Related Experiment Videos

    Last Updated: May 23, 2026

    Hybrid Ensemble and Single-molecule Assay to Image the Motion of Fully Reconstituted CMG
    10:11

    Hybrid Ensemble and Single-molecule Assay to Image the Motion of Fully Reconstituted CMG

    Published on: July 26, 2024

    CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion
    07:37

    CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion

    Published on: June 25, 2017

    Origami Inspired Self-assembly of Patterned and Reconfigurable Particles
    12:33

    Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

    Published on: February 4, 2013