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Published on: February 10, 2026
[Acute postinfectious glomerulonephritis]
Benyounès Ramdani1, Mohamed Zamd, Khadija Hachim
1Service de Néphrologie Hémodialyse, Centre Hospitalier Ibn-Rochd, Casablanca, Maroc. benyounsramdani@gmail.com
Nephrologie & Therapeutique
|April 10, 2012
Summary
Acute postinfectious glomerulonephritis, often caused by Streptococcus, involves kidney inflammation. While uncommon in adults and declining, early infection treatment and hygiene can prevent this condition.
Area of Science:
- Nephrology
- Immunology
- Infectious Diseases
Context:
- Acute postinfectious glomerulonephritis (APIGN) is an inflammatory kidney condition.
- Its incidence is unclear due to frequent subclinical cases.
- Beta-hemolytic Streptococcus group A is the most common causative agent.
Purpose:
- To define acute postinfectious glomerulonephritis.
- To outline its pathogenesis, clinical presentation, and epidemiology.
- To discuss treatment and prevention strategies.
Summary:
- APIGN results from an acute, nonsuppurative inflammatory insult primarily affecting the glomeruli.
- Humoral immunity and complement activation (alternative and lectin pathways) are key to kidney damage.
- The classic presentation includes acute nephritic syndrome following a streptococcal infection, though it's uncommon in adults and declining in developed nations.
Impact:
- Highlights the role of humoral immunity and complement pathways in APIGN pathogenesis.
- Emphasizes symptomatic treatment and preventive measures like hygiene and prompt infection management.
- Underscores the declining incidence and rarity in adults, suggesting improved public health measures.
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