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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Occupational nonasthmatic eosinophilic bronchitis: current concepts.

G Pala1, Patrizia Pignatti, Gianna Moscato

  • 1Allergy and Immunology Unit, Fondazione "Salvatore Maugeri", Institute of Care and Research, Scientific Institute of Pavia, Italy. giannipalass@libero.it

La Medicina Del Lavoro
|April 11, 2012
PubMed
Summary

Nonasthmatic eosinophilic bronchitis (NAEB), a common cause of chronic cough, may be occupationally acquired. This condition, characterized by bronchial inflammation, is likely underdiagnosed and warrants inclusion in occupational respiratory disorder classifications.

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Area of Science:

  • Respiratory Medicine
  • Occupational Health
  • Immunology

Background:

  • Nonasthmatic eosinophilic bronchitis (NAEB) affects 10-15% of patients with chronic cough.
  • NAEB is considered a variant of occupational asthma when linked to workplace exposures.
  • It falls within the spectrum of work-related airway diseases.

Purpose of the Study:

  • To update and expand knowledge on NAEB's clinical and pathophysiological aspects.
  • To analyze occupational causes of NAEB.
  • To review literature from 1990-2010.

Main Methods:

  • Medline literature search (1990-2010).
  • Review of clinical and pathophysiological data.
  • Analysis of occupational exposure data.

Main Results:

  • NAEB is likely underdiagnosed.
  • Occupational origins are rarely confirmed, possibly due to disease rarity and insufficient bronchial inflammation assessment.
  • Systematic evaluation of bronchial inflammation is lacking.

Conclusions:

  • Occupational NAEB should be recognized as a significant occupational respiratory disorder.
  • Advances in evaluating bronchial inflammation support its inclusion in occupational disease categories.
  • NAEB's occupational link cannot be overlooked.