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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
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Is it time for a simplified method to evaluate airway eosinophilia?
Patrizia Pignatti1, Antonio Spanevello2,3
1Allergy and Immunology Unit, Istituti Clinici Scientifici Maugeri, IRCCS, Pavia, Italy.
ERJ Open Research
|January 7, 2026
Summary
Induced sputum is a valuable tool for assessing airway inflammation but is often impractical. New methods are needed to gather crucial inflammatory data for asthma patients.
Area of Science:
- Pulmonology
- Medical Diagnostics
Background:
- Induced sputum analysis is a key method for evaluating airway inflammation in respiratory diseases.
- Current limitations include time constraints and limited availability in many asthma centers.
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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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