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Non-Helicobacter pylori gastritis is common among paediatric patients with inflammatory bowel disease

R M Genta1, A Sonnenberg

  • 1Miraca Life Sciences, Irving, TX, USA.

Alimentary Pharmacology & Therapeutics
|April 11, 2012
PubMed

Insights

Pediatric inflammatory bowel disease (IBD) patients show higher rates of Helicobacter-negative gastritis and duodenitis. Crohn's disease patients exhibit the most significant age-specific patterns for these upper gastrointestinal conditions.

Area of Science:

  • Gastroenterology
  • Pediatric Gastroenterology
  • Inflammatory Bowel Disease Research

Background:

  • Helicobacter-negative gastritis and duodenitis are more prevalent in inflammatory bowel disease (IBD) patients compared to controls.
  • Preliminary data suggest a higher incidence of these conditions in pediatric IBD populations.

Purpose of the Study:

  • To investigate the age-specific prevalence of gastritis and duodenitis in pediatric IBD patients.
  • To compare the occurrence of these upper gastrointestinal issues in children with and without IBD.

Main Methods:

  • A retrospective analysis of 344 pediatric IBD patients (ages 0-21) and 4241 non-IBD controls.
  • Inclusion criteria involved colonoscopy and esophago-gastro-duodenoscopy with biopsy results.

Main Results:

  • Helicobacter-negative chronic active gastritis was diagnosed in 20% of IBD patients versus 2% of controls.
  • Duodenitis affected 17% of IBD patients compared to 2% of controls.
  • Crohn's disease patients showed higher rates (26% gastritis, 28% duodenitis) than ulcerative colitis patients.

Conclusions:

  • Pediatric IBD patients have a significantly higher incidence of Helicobacter-negative gastritis and duodenitis.
  • These upper gastrointestinal inflammatory conditions are particularly common in pediatric Crohn's disease.
  • The findings highlight the importance of evaluating the upper GI tract in children with IBD.
Abstract

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