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Related Experiment Video

Updated: May 23, 2026

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma
05:44

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Published on: November 5, 2020

Invasive markers identified by gene expression profiling in pancreatic cancer.

A Rogers1, M J Smith, P Doolan

  • 1Department of Surgery, Trinity College Dublin, The Adelaide and Meath Hospital Incorporating the National Children's Hospital, Tallaght, Dublin 24, Ireland.

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [Et Al.]
|April 11, 2012
PubMed
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Researchers identified three gene expression markers (uPA, MMP-1, IL1-R1) that may distinguish pancreatic ductal adenocarcinoma (PDAC) from other tumors and indicate invasive potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Molecular profiling is valuable in oncology but a specific gene expression profile for pancreatic cancer is needed.
  • Identifying such a profile could improve diagnosis and treatment prediction.

Purpose of the Study:

  • To identify a clinically relevant gene expression profile in pancreatic cancer.
  • To find potential invasive markers for pancreatic ductal adenocarcinoma (PDAC).

Main Methods:

  • Gene expression analysis of pancreatic cancer cell lines stimulated with phorbol-12-myristate 13-acetate (PMA).
  • Microarray analysis, quantitative real-time PCR, and bioinformatic analysis.
  • Validation in human pancreatic tumor samples.

Main Results:

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Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
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Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

Related Experiment Videos

Last Updated: May 23, 2026

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma
05:44

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Published on: November 5, 2020

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
10:33

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

  • Three potential invasive markers (uPA, MMP-1, IL1-R1) were identified.
  • These markers differentiated PDAC from other pancreatic neoplasms.
  • IL1-R1 expression in PDAC is a novel finding; MMP-1 expression correlated with high-grade PDAC.

Conclusions:

  • uPA, MMP-1, and IL1-R1 are potential invasive markers for pancreatic cancer.
  • These markers may help differentiate PDAC from other neoplasms.
  • The identified markers could reflect a more invasive tumor phenotype.